Carpal Tunnel Syndrome is a painful condition of the hand caused by compression of the median nerve which runs through the wrist in between the muscles of the forearm.  The median nerve is situated on the palm side of the hand and it runs down the wrist through a structure known as the carpal tunnel. The median nerve is a main peripheral nerve and supplies blood to the thumb, forefinger, middle finger and half of the ring finger all on the palm side. Therefore, any dysfunction along the median nerve can cause numbness, pins and needles, and pain anywhere along the palm of the hand. Pain from the median nerve is often worse at night and if left untreated, it can cause weakness in the forearm and loss of grip.